Cisplatin hplc method

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August undefined, 2024

WebMar 11, 2024 · Cisplatin (CDDP), a platinum-based drug, is the most potent anti-cancer agent and is widely used for cancer treatment [ 1 ]. In particular, it plays crucial roles in … WebCisplatin, referred to by chemical name as cis-diamminedichloroplatinum (II), is anticancer, neutral and DNA destroying agent that is square planar platinum (II) complex and contains 2 ligands of chloride in a cis configuration orientation. 1 Cisplatin has been cited as being among the most used cytotoxic anticancer medication due to its ...

HPLC Analysis of Cisplatin Analogues in Biological Fluids

WebCisplatin is an anti-tumor agent widely employed in cancer chemotherapy. A specific and selective method for the quantitative determination of cisplatin in human plasma and its … WebCisplatin was the first of the platinum-based chemotherapeutic agents and therefore has been extensively studied as an antitumor agent since the late 1960s. Because this agent … christian leukauf

On the complexity and dynamics of in vivo Cisplatin–DNA adduct ...

WebIn this work, a new sensitive and selective method of determining cisplatin-DNA adducts based on the use of element-selective mass spectrometry is proposed, and the method is then applied to detect cisplatin adducts induced … WebMar 1, 2024 · Cisplatin is a platinum containing compound used for the treatment of different types of cancers. Quantitative determination of cisplatin has been carried out … WebAreas covered: In this review, we have discussed about cisplatin and its liposomal formulations, focusing on different preparation methods and analysis approaches such as atomic absorption, mass spectroscopy, UV, electrochemical methods, and emphasizing on HPLC as one of the accurate and specific methods for determination of cisplatin … la seine vanessa paradis mp3

Cisplatin: Uses, Interactions, Mechanism of Action - DrugBank

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WebHypoxia can induce chemoresistance, which is a significant clinical obstacle in cancer therapy. Here, we assessed development of hypoxia-induced chemoresistance (HICR) against free versus polymeric cisplatin micelles in a triple negative breast cancer cell line, MDA-MB-231. We then explored two strategies for the modulation of HICR against … WebCisplatin hydrochloride is an important chemotherapeutic drug for cancer treatment. It has a low molar absorptivity in the UV region and has no fluorescence. Therefore, a selective … la semillitaWebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared. la sella spain

"WebWe successfully determined cisplatin, hydroxo complexes, and OH-dimer by HPLC using a πNAP column. Thus the measurement of cisplatin (cis-diamminedichloro-platinum(II), cis-[PtCl2(NH3)2]) (CDDP) should be done using a πNAP column rather than a C18 column or aminopropylsilyl silica gel column. " - Cisplatin hplc method

Cisplatin hplc method

Development of a novel chromatographic method for concurrent ...

WebNational Center for Biotechnology Information WebJul 13, 2016 · The HPLC method was successfully applied to in vitro studies and enabled us to quantify CDDP not only in the NaCl medium but also in the cellular lysates using only 0.02 mL of a sample. Our results clearly demonstrate that the intracellular CDDP concentrations in EHD1-overexpressing cells were lower than those in control cells.

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WebSep 1, 2024 · Application of a newly developed HPLC method to evaluate the drug release of co-loaded 5-fluorouracil and cisplatin films. Abstract The combination of 5-fluorouracil (5-FU) and cisplatin (Cis) has been used for the treatment of many cancers. WebDownload scientific diagram Cisplatin determination by HPLC method. Chromatogram shows the peak of chelating agent, diethyldithiocarbamate (DDTC), and cisplatin in …

WebMethods: A microemulsion method was employed to generate lipid coated cisplatin/oleanolic acid calcium carbonate nanoparticles (CDDP/OA-LCC NPs), and the loading concentration of CDDP and OA was measured by atomic absorption spectroscopy and HPLC respectively.Transmission electron microscopy (TEM) was used to examine … WebThe platinum content (4.91%) of Polycisplatin was determined by modified HPLC–UV method detailed in the literature. 19 Briefly, a known amount of Polycisplatin was dissolved in 0.5 M HCl solution and stirred so as to cleave the AA-Pt bond and release the cisplatin. The cisplatin was then treated with 100 µL of (10%) DDTC in 0.1 N NaOH and ...

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … WebRP-HPLC METHOD FOR THE QUANTIFICATION OF OXALIPLATIN IN FORMULATIONS SUBHASHINI.EDLA, B.SYAMA SUNDHAR Dept. of Chemistry, Acharya Nagarjuna …

WebAug 15, 2007 · The HPLC method was developed for individual as well as simultaneous determination of two drugs namely carboplatin and paclitaxel in the presence of polymer …

WebA high-performance liquid chromatographic (HPLC) method is described for the determination of residual levels of cisplatin from extracts of surfaces with very low … christian luisiWebCisplatin, cis-diamminedichlorido-platinum(II), is an important therapeutic tool in the struggle against different tumors, yet it is plagued with the emergence 掌桥科研一站式科研服务平台 la seine vanessa paradis youtubeWebThe HPLC system (LC-20AD model, Shimadzu, Kyoto, Japan) consisted of two pumps (LC 20-AT model), an automatic injector (9SIL-20AD model), an oven (CTO-20AS model), a spectrophotometric detector (SPD-M20A model), and a computer equipped with the analysis software Shimadzu LC. la sebastiana valparaisoWebA method of preparation and physical properties including the pK a of several species of cisplatin in water,2 the UV and visible spectra, HPLC methods, and mass spectra have been reported.1 Cisplatin is a platinum-containing, broad activity antineoplastic and alkylating agent effective against solid tumors of testes, ovaries, and bladder ... la senator kennedy quotesWebJun 13, 2005 · Cisplatin, cisplatinum or cis-diamminedichloroplatinum (II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes … christian loisy la selleria onlineWebMaterials and Methods Chemicals. Reduced glutathione (GSH), glutathione oxidized, and g-glutamyl glutamate, superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, solvents of analytical grade (methanol and glacial acetic acid) used for HPLC, thioctic acid (a-lipoic acid, oxidized form) and cisplatin were purchased ... la senator john kennedy quotes