Splet15. maj 2024 · AAV9-PCSK9 injection followed by partial carotid ligation is an effective and time-saving approach to rapidly induce atherosclerosis. This accelerated model is well … SpletAAV-PCSK9 effectively reduces LDL receptors in mouse. Our goal was to express PCSK9 in the mouse liver to effectively knockdown the LDL receptors. To this end, we used AAV9 …
Addgene: pAAV/D377Y-mPCSK9
Splet01. avg. 2016 · Total cholesterol levels in the PCSK9 AAV group increased to similar levels of those of Ldlr–/– over the 20 weeks of HF/HC diet. Mice consuming a HF/HC diet for 30 weeks (n = 2) after PCSK9 AAV injection retained elevated plasma PCSK9 and total cholesterol ( Supplementary Fig. 1A, B ). Splet24. sep. 2024 · These results indicated that AAV-PCSK9 injection could successfully trigger atherosclerosis plaque formation in db/db mice after feeding a high-cholesterol diet within 8 weeks. This model is also suitable for assessing plaque composition. Download : Download high-res image (1MB) Download : Download full-size image Fig. 2. can mobs spawn on ladders
National Center for Biotechnology Information
Splet18. mar. 2024 · In this study, researchers find that adeno-associated virus (AAV) delivers CRISPR/Cas9 to achieve Ldlr gene correction that can partially rescue LDLR expression and effectively ameliorate atherosclerosis phenotypes … Splet05. dec. 2024 · The so called pro-protein convertase subtilisin/kexin type 9 (PCSK9) - adeno associated virus (AAV) mice were described independently by two research groups in … Splet03. avg. 2014 · AAV-mediated gene transfer of STAT3 in LDLR-deficient mice reduced the invasion of inflammatory cells into the vessel wall, resulting in a reduction in the severity of atherosclerosis as measured by decreased wall thickness and lower blood flow velocity . In the hope of achieving a supra-additive effect, investigators treated LDLR-deficient ... can mobs spawn on diamond blocks