Penta-class refractory
Web1. jan 2024 · Selinexor is a first-in-class selective inhibitor of nuclear export that provides an additional therapeutic option for those with triple-refractory disease. 36 Selinexor has been studied in patients with quad- and penta-refractory disease because of their exposure to, and having become refractory to the 5 key agents used in this patient … WebOÄ Dr. Sabine Burger von der 3. Medizinischen Abteilung am Hanusch-Krankenhaus gibt einen Überblick über die neuen Myelom-Studien vom ASH 2024, darunter ein möglicherweise kuratives Konzept und eine neue Methode, die Patienten häufige Knochenmarkspunktionen ersparen könnte.
Penta-class refractory
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Web29. nov 2024 · Patients with quad-refractory MM (refractory to bortezomib, carfilzomib, lenalidomide, and pomalidomide) and penta-refractory MM (refractory to an anti-CD38 … Web23. nov 2024 · Pts with triple-class refractory disease (refractory to one class of the following: immunomodulatory agents (IMiDs), proteasome inhibitors (PI) and anti-CD38 …
WebA good example for the unmet medical need of patients with triple class refractory myeloma in early lines can be found in the recently published KarMMa-3 study, comparing a CART cell therapy to a choice of five different standard regimens in myeloma patients with two to four prior treatments. 1 The median PFS was less than 5 months in the ... Web13. nov 2024 · Overall Survival of Triple Class Refractory, Penta-Exposed Multiple Myeloma (MM) Patients Treated with Selinexor Plus Dexamethasone or Conventional Care: A Combined Analysis of the STORM and Mammoth Studies L. Costa, P. Hari, +23 authors R. Cornell Published 13 November 2024 Medicine Blood
Web13. nov 2024 · For this analysis, we pooled 78 patients (48 quad-refractory and 30 penta-refractory) from STORM, part 1 and 122 patients (penta-exposed and triple class … Web5. nov 2024 · Penta-exposed was defined as having prior exposure to bortezomib, carfilzomib, lenalidomide and pomalidomide and daratumumab. Penta or quad refractory …
WebTriple-class b: 125 (100) Penta-class c: 90 (72.0) Refractory status Triple-class b: 96 (76.8) Penta-drug c: 34 (27.2) Abbreviations: ECOG PS, Eastern Cooperative Oncology Group Performance Status; mAb, monoclonal antibody; PI, proteasome inhibitor. a …
Webtients with refractory multiple myeloma. There are a number of promising new immunotherapeutic options such as CART ... patients may become triple-refractory or even penta- refractory long before they have reached three or more lines of ... with triple class refractory myeloma in early lines can be found in the recently published KarMMa-3 study ... clay pottery kits for adultsWeb5. nov 2024 · Interestingly, iopofosine I-131 showed its highest efficacy in patients that were quad/penta drug refractory with ORR of 80%, highlighting its potential as a later line therapy. Iopofosine I-131 is a novel cancer radiotherapeutic that may provide benefit to patients that are refractory/unresponsive to traditional MM therapies. clay pottery terminologyWeb1. jan 2024 · The first part of the phase II trial evaluated selinexor and dexamethasone in patients with MM refractory to bortezomib, carfilzomib, lenalidomide, and pomalidomide … clay pottery kits for kidsWebpentaexposed, tripleclass refractory myeloma with a minimal threshold of 10% of patients with a partial response or better.19 For the pri mary efficacy analysis, a sample of 122 … down otcWebThe current approaches to the treatment of triple-class refractory disease are limited and include conventional chemotherapy, salvage autologous stem cell transplantation, and … down or syntheticWebReal-World Outcomes of Triple-Class Refractory, Penta-Exposed RRMM Conference Correspondent Categories: IMW 2024 Multiple Myeloma Outcomes for patients with … down our streethttp://jons-online.com/issues/2024/may-2024-vol-9-no-5?view=article&artid=2551:real-world-outcomes-of-triple-class-refractory-penta-exposed-rrmm clay pottery without wheel