Rab11 family-interacting protein 5
WebNX_Q9BXF6 - RAB11FIP5 - Rab11 family-interacting protein 5 - Function. Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. WebThe Rab11-FIPs (Rab11-family interacting proteins; also known as FIPs) constitute an evolutionarily conserved protein family that act as effector molecules for multiple Rab and Arf (ADP-ribosylation factor) GTPases. They were initially characterized by their ability to bind Rab11 subfamily members v …
Rab11 family-interacting protein 5
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WebJul 5, 2024 · The structure of the uncomplexed Rab-binding domain of Rab11 family-interacting protein 2 has been determined at 2.3 Å resolution. The structure reveals antiparallel α-helical dimers that associate in the crystal lattice through polar interactions. The dimers assemble into a four-helix bundle in the lattice that is brought together by a … WebAug 6, 2004 · The Rab11 subfamily of GTPases plays an important role in vesicle trafficking from endosomes to the plasma membrane. At least six Rab11 effectors (family of Rab11-interacting proteins (FIPs)) have been shown to interact with Rab11 and are hypothesized to regulate various membrane trafficking pathways such as transferrin recycling, …
WebJan 8, 2024 · Abstract. Mammalian myosin-5b (Myo5b) plays a critical role in the recycling of endosomes to the plasma membrane via the interactions with Rab11a and the Rab11 family interacting protein 2 (FIP2). However, it remains unclear on how Rab11a and FIP2 are coordinated in tethering Myo5b with the vesicles and activating the motor function of …
WebAug 18, 2024 · In a yeast 2-hybrid screen to identify VPS33B (608552)-interacting proteins, Cullinane et al. (2010) found that the protein encoded by C14ORF133, which they designated VIPAR, had highest priority based on bioinformatic analyses of … WebMay 27, 2004 · RAB11 (see RAB11A; 605570) is a GTPase that regulates endosomal trafficking to apical plasma membrane domains in polarized epithelial cells.Using protein …
WebJun 6, 2024 · In the ensemble, there are many Rab11 structures that are co-crystallized with interacting partners such as Myosin 5a, Myosin 5b, family-interacting protein 2 (FIP2), family-interacting protein 3 (FIP3), Rabin8, P14KB and PKGII. We observed separate clustering of most of the Rab11structures co-crystallized with distinct interacting partners …
WebNX_Q9BXF6 - RAB11FIP5 - Rab11 family-interacting protein 5 - Interactions. Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma … shiro defaultsecuritymanagerWebGene ID: 101103391, updated on 16-Oct-2024. Summary Other designations. rab11 family-interacting protein 5 quotes by ray dalioWebAuthor(s): Rahman, Farhana; Johnson, Jennifer L; Zhang, Jinzhong; He, Jing; Pestonjamasp, Kersi; Cherqui, Stephanie; Catz, Sergio D Abstract: The dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated and the importance of individual subunits in … shiro deadman wonderland quotesWebJan 1, 2010 · A group of proteins that interact with Rab11 and function as Rab11 effectors are identified, known as the Rab11‐FIPs (family interacting proteins), and this protein family has been sub‐classified into two groups—class I FIPs [FIP2, RCP and Rip11 (Rab11‐interacting protein)] and class II F IPs (FIP3 and FIP4). Background information. … shiroda bus standWebRab11 proteins have been shown to play a role in protein trafficking from endosomes to PM and TGN, as well as for polarized transport in epithelial cells, insulin dependent GLUT4 transport and phagocytosis [71 ]. Both members of Rab11 family proteins are ubiquitously expressed in every cell type [ 72 ]. shirodbrealmWebThe pp75/Rip11 protein is a member of a larger group of Rab11 family interacting proteins (Rab11-FIPs). Rab11-FIP1, Rab11-FIP2, Rab11-FIP3, Rab11-FIP4, Rab coupling protein (RCP), and pp75/Rip11 all interact with Rab11a through a conserved carboxyl-terminal amphipathic α-helical domain ( shiro davis college statsRab11FIP5 is one of the many proteins that have been shown to interact with the Rab11 protein. Rab GTPases, such as Rab11, are enzymes that are involved in vesicular trafficking. Rab11 specifically plays a key role in endocytic trafficking and recycling through guiding early endosomes to endosome … See more Rab11 family-interacting protein 5 is a protein that in humans is encoded by the RAB11FIP5 gene. See more RAB11FIP5 has been shown to interact with RAB11A and RAB25. See more • Wang D, Buyon JP, Zhu W, Chan EK (November 1999). "Defining a novel 75-kDa phosphoprotein associated with SS-A/Ro and identification of distinct human autoantibodies" See more Rab11FIP5 has been shown to play a role in the nervous system because it functions in neurons. Studies have suggested that Rab11FIP5 is … See more quotes by red sox players